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3 Beds
4 Baths
1,630 sqft

$998,888

643 Grand Avenue, South San Francisco CA, 94080

Price per sqft$612.81
Built in1895
Property size1,630 sqft
Property typeResidential
Listed by Jill Penna CA DRE# 01895080 with Christie's International Real Estate Sereno 415-244-8630

Overview

Active

Listed Aug 27, 2026

Updated 16h ago

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

$6,646/mo

Est. mortgage payment based on a $998,888 home price.

All estimates are provided by Luxury Presence for informational purposes only. Actual amounts may vary.

Additional information

MLS® ID
ML82059314

Interior Features

Bedrooms
3
Bathrooms
4
Cooling
Yes
Heating
Yes
Basement
No

Exterior Features

Lot Size
0.08 Acres

Other Property Details

Garage
Yes
MLS provider logo

Listed by Jill Penna CA DRE# 01895080 with Christie's International Real Estate Sereno 415-244-8630

Based on information from the California Regional Multiple Listing Service (CRMLS) as of 10/7/2026. This information is for your personal, non-commercial use and may not be used for any purpose other than to identify prospective properties you may be interested in purchasing. Display of MLS data is usually deemed reliable but is NOT guaranteed accurate by the MLS. Buyers are responsible for verifying the accuracy of all information and should investigate the data themselves or retain appropriate professionals. Information from sources other than the Listing Agent may have been included in the MLS data. Unless otherwise specified in writing, the Broker/Agent has not and will not verify any information obtained from other sources. The Broker/Agent providing the information contained herein may or may not have been the Listing and/or Selling Agent. Property locations as displayed on any map are best approximations only and exact locations should be independently verified. Any offer of compensation is made only to participants of the MLS where the listing is filed.

©2026 California Regional Multiple Listing Service (CRMLS) all rights reserved.

Data last updated on 10/7/2026 at 6:37 AM UTC Last Checked: 6:37 AM UTC

 

 

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